Author: Liu, Weiwei; Ding, Chan
Title: Roles of LncRNAs in Viral Infections Document date: 2017_5_26
ID: 02zv1gsq_23
Snippet: In addition, several virus-and host cell-encoded factors, including histones (H1 and H2A), mitochondrial and cellular single-stranded binding proteins (SSBPs) and interferon regulatory factor 4 (IRF4), interact with PAN (Rossetto and Pari, 2011) . LANA is essential for maintaining the episomal form of the viral genome during latency (Ballestas et al., 1999; Uppal et al., 2014) . PAN promotes LANA-episome disassociation through an interaction with.....
Document: In addition, several virus-and host cell-encoded factors, including histones (H1 and H2A), mitochondrial and cellular single-stranded binding proteins (SSBPs) and interferon regulatory factor 4 (IRF4), interact with PAN (Rossetto and Pari, 2011) . LANA is essential for maintaining the episomal form of the viral genome during latency (Ballestas et al., 1999; Uppal et al., 2014) . PAN promotes LANA-episome disassociation through an interaction with LANA which facilitates LANA sequestration away from KSHV episomes during reactivation (Campbell et al., 2014) . Overall, these studies have revealed that PAN as a major global regulator plays an important role in regulation of viral and host gene expression (Rossetto and Pari, 2014) .
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