Selected article for: "genome sequence and viral genome"

Author: Liu, Weiwei; Ding, Chan
Title: Roles of LncRNAs in Viral Infections
  • Document date: 2017_5_26
  • ID: 02zv1gsq_32
    Snippet: In addition to the cellular lncRNAs and virus encoded lncRNAs, HBx-LINE1 was identified as a chimeric lncRNA, which is produced by viral integration into the host genome leading to activation of a LINE-1 sequence such that a chimeric lncRNA is produced (Lau et al., 2014; Moyo et al., 2016) . HBx-LINE functions as an lncRNA-like RNA in HBV-positive HCC cell lines, which induces the Wnt pathway by increasing the nuclear localization of β-catenin. .....
    Document: In addition to the cellular lncRNAs and virus encoded lncRNAs, HBx-LINE1 was identified as a chimeric lncRNA, which is produced by viral integration into the host genome leading to activation of a LINE-1 sequence such that a chimeric lncRNA is produced (Lau et al., 2014; Moyo et al., 2016) . HBx-LINE functions as an lncRNA-like RNA in HBV-positive HCC cell lines, which induces the Wnt pathway by increasing the nuclear localization of β-catenin. So far, it remains unknown whether other chimeric lncRNAs are identified and their roles in the virus infection.

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