Selected article for: "early stage and future study"
Author: Liu, Weiwei; Ding, Chan
Title: Roles of LncRNAs in Viral Infections
  • Document date: 2017_5_26
    • ID: 02zv1gsq_35
    Snippet: In addition to the role of lncRNA associated with the antivirus response, lncRNAs may be both unique diagnostic biomarkers as well as novel targets against which new therapeutics can be developed. Virus-related lncRNAs secreted into the serum may serve as prognostic markers. For example, two serum lncRNAs, uc001ncr and AX800134, have potential as novel potential biomarkers to diagnose HBV-positive HCC, especially in the early stage of disease . T.....
    Document: In addition to the role of lncRNA associated with the antivirus response, lncRNAs may be both unique diagnostic biomarkers as well as novel targets against which new therapeutics can be developed. Virus-related lncRNAs secreted into the serum may serve as prognostic markers. For example, two serum lncRNAs, uc001ncr and AX800134, have potential as novel potential biomarkers to diagnose HBV-positive HCC, especially in the early stage of disease . The expression of lncRNA-UCA1 and lncRNA-WRAP53 were significantly higher in sera of HCC than in chronic HCV infection or healthy volunteers (Kamel et al., 2016) . This result suggests that lncRNA-UCA1 and lncRNA-WRAP53 upregulation may serve as novel serum biomarkers for HCC diagnosis and prognosis. In conclusion, lncRNAs are key regulators of transcriptional and post-transcriptional processes; thus, their roles in virus infection and therapy necessitate intensive study in the future.

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