Author: Sun, Di; Chen, Shun; Cheng, Anchun; Wang, Mingshu
Title: Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells Document date: 2016_3_17
ID: 07nfb69o_45
Snippet: When toll-like receptor 3 (TLR3) recognizes double-stranded RNA, it recruits TIR domain-containing adapter inducing interferon-β (TRIF) [95] , which together activate downstream IKK-related kinases. These kinases phosphorylate interferon regulatory factor 3 (IRF3), leading to the expression of IFN-α/β [96] [97] [98] [99] [100] . MDA5 and RIG-I, two activated DExD/H box RNA helicases, transmit signals to downstream adaptor IPS-I, leading to sti.....
Document: When toll-like receptor 3 (TLR3) recognizes double-stranded RNA, it recruits TIR domain-containing adapter inducing interferon-β (TRIF) [95] , which together activate downstream IKK-related kinases. These kinases phosphorylate interferon regulatory factor 3 (IRF3), leading to the expression of IFN-α/β [96] [97] [98] [99] [100] . MDA5 and RIG-I, two activated DExD/H box RNA helicases, transmit signals to downstream adaptor IPS-I, leading to stimulation of NF-κB and IFN-β. The expression of IFN-α/β depends on the activation of IRF3, and this process is closely related to the interactions among IPS-I, TRF3 and TBK1/IKKi [101, 102] .
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