Author: Liu, Weiwei; Ding, Chan
Title: Roles of LncRNAs in Viral Infections Document date: 2017_5_26
ID: 02zv1gsq_31
Snippet: Two highly structured cytoplasmic RNAs; named VA RNA I and VA RNA II (∼160-170 nts) are produced from RNA polymerase III (pol III) (Mathews and Shenk, 1991) . The VA RNAs bind Dicer and function as competitive substrates suppressing Dicer to inhibit the RNAi (Andersson et al., 2005) . Notably, compared with VA RNAI, VA RNA II is incorporated into the RNA-induced silencing complex (RISC) (Xu et al., 2007) . Adenovirus VA RNA binds PKR and blocks.....
Document: Two highly structured cytoplasmic RNAs; named VA RNA I and VA RNA II (∼160-170 nts) are produced from RNA polymerase III (pol III) (Mathews and Shenk, 1991) . The VA RNAs bind Dicer and function as competitive substrates suppressing Dicer to inhibit the RNAi (Andersson et al., 2005) . Notably, compared with VA RNAI, VA RNA II is incorporated into the RNA-induced silencing complex (RISC) (Xu et al., 2007) . Adenovirus VA RNA binds PKR and blocks PKR activity, avoiding phosphorylation of eIF-2a and inhibition of viral mRNA translation (Clarke and Mathews, 1995) .
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