Author: Sun, Di; Chen, Shun; Cheng, Anchun; Wang, Mingshu
Title: Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells Document date: 2016_3_17
ID: 07nfb69o_61
Snippet: Inhibition of host protein synthesis via cleavage of proteins required for transcription and cap-dependent translation can also block the production and transportation of antiviral proteins. In addition to innate immune responses, picornaviruses employ diverse mechanisms to suppress antiviral responses. There are some similarities and differences among various genera. With the help of precursors and the cooperation of other viral proteinases, 3C .....
Document: Inhibition of host protein synthesis via cleavage of proteins required for transcription and cap-dependent translation can also block the production and transportation of antiviral proteins. In addition to innate immune responses, picornaviruses employ diverse mechanisms to suppress antiviral responses. There are some similarities and differences among various genera. With the help of precursors and the cooperation of other viral proteinases, 3C pro has a crucial role in down-regulating type I IFN, pro-inflammatory cytokines and ISG induction. Picornavirus-infected cells engage multiple mechanisms. For example, the PARP9-DTX3L complex promotes ISG expression and induces degradation of viral 3C pro to enhance the immune response. The cleavage of TDP-43 is a major molecular marker for some neurodegenerative diseases, and TDP-43 cleavage by the 3C pro of CVB3 provides a novel model for viral pathogenesis research.
Search related documents:
Co phrase search for related documents- antiviral protein and host protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral protein and host protein synthesis: 1, 2, 3, 4, 5, 6, 7, 8
- antiviral protein and host protein synthesis inhibition: 1
- antiviral protein and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral protein and immune response innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral protein and ISG expression: 1, 2
- antiviral protein and ISG induction: 1, 2, 3
- antiviral response and crucial role: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- antiviral response and diverse mechanism: 1
- antiviral response and host protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral response and host protein synthesis: 1, 2, 3, 4, 5
- antiviral response and host protein synthesis inhibition: 1, 2, 3
- antiviral response and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral response and immune response enhance: 1, 2, 3, 4
- antiviral response and immune response innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral response and immune response innate addition: 1, 2, 3, 4
- antiviral response and ISG expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- antiviral response and ISG induction: 1, 2, 3, 4, 5, 6, 7, 8
- antiviral response suppress and host protein: 1
Co phrase search for related documents, hyperlinks ordered by date