Author: Shen, Zu T.; Sigalov, Alexander B.
Title: SARS Coronavirus Fusion Peptide-Derived Sequence Suppresses Collagen-Induced Arthritis in DBA/1J Mice Document date: 2016_6_28
ID: 10wcqgaq_3
Snippet: In this study, we demonstrate that a synthetic 11 amino acid-long peptide (MG11) derived from SARS CoV FP reduces inflammation in DBA/1J mice with collagen-induced arthritis (CIA) and protects mice against bone and cartilage damage. The effect is specific as administration of the control peptide has no effect. Incorporation of MG11 into synthetic nanoparticles that mimic human high density lipoproteins (HDL) substantially reduces the effective pe.....
Document: In this study, we demonstrate that a synthetic 11 amino acid-long peptide (MG11) derived from SARS CoV FP reduces inflammation in DBA/1J mice with collagen-induced arthritis (CIA) and protects mice against bone and cartilage damage. The effect is specific as administration of the control peptide has no effect. Incorporation of MG11 into synthetic nanoparticles that mimic human high density lipoproteins (HDL) substantially reduces the effective peptide dosage. In summary, our data demonstrate for the first time that SARS-CoV FP does not only have fusogenic, but also immunomodulatory activity. This study provides compelling experimental in vivo evidence in support of our hypothesis 29 and further confirms that viral immune evasion strategies evolved during host-virus co-evolution can be transferred to therapeutic strategies that require similar functionalities (e.g., in the treatment of autoimmune diseases).
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