Author: Sun, Di; Chen, Shun; Cheng, Anchun; Wang, Mingshu
Title: Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells Document date: 2016_3_17
ID: 07nfb69o_25
Snippet: Numerous studies have focused on how picornaviruses switch from translation to replication, and the cleavage of PCBP2 by 3CD pro may provide mechanism [46] . For PV, a model has been proposed in which full-length PCBP2 functions in viral translation, but the cleavage product of PCBP2 functions in RNA replication [47] . Both 3C pro and 3CD pro interact with phosphoinositide lipids to regulate the maturation of virus replication organelles and serv.....
Document: Numerous studies have focused on how picornaviruses switch from translation to replication, and the cleavage of PCBP2 by 3CD pro may provide mechanism [46] . For PV, a model has been proposed in which full-length PCBP2 functions in viral translation, but the cleavage product of PCBP2 functions in RNA replication [47] . Both 3C pro and 3CD pro interact with phosphoinositide lipids to regulate the maturation of virus replication organelles and serve as the main protease to cleave virus and host proteins to regulate processes of both. However, the protease specificities and RNA-binding capabilities of 3C pro and 3CD pro are different. The proteolytic processing of the C-terminal end of 3C pro may cause the switch of activities from 3CD pro to 3C pro to modulate functions during the virus cycle [48] . Above all, 3C pro plays a major role in regulating translation and replication by binding to RNA sequences.
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