Author: Shen, Zu T.; Sigalov, Alexander B.
Title: SARS Coronavirus Fusion Peptide-Derived Sequence Suppresses Collagen-Induced Arthritis in DBA/1J Mice Document date: 2016_6_28
ID: 10wcqgaq_10
Snippet: In summary, these data collectively indicate that the SARS-CoV FP-derived peptide MG11 generates a strong anti-arthritic effect in the CIA mouse model of RA, thereby providing the first experimental in vivo evidence of previously predicted immunomodulatory activity of SARS-CoV FP 29 . Incorporation of MG11 into spherical HDL-like synthetic particles substantially reduces the effective dosage of peptide probably because of the prolonged circulator.....
Document: In summary, these data collectively indicate that the SARS-CoV FP-derived peptide MG11 generates a strong anti-arthritic effect in the CIA mouse model of RA, thereby providing the first experimental in vivo evidence of previously predicted immunomodulatory activity of SARS-CoV FP 29 . Incorporation of MG11 into spherical HDL-like synthetic particles substantially reduces the effective dosage of peptide probably because of the prolonged circulatory half-life afforded by this strategy.
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