Selected article for: "apoptotic protein and pro apoptotic protein"
Author: Pervushin, Konstantin; Tan, Edward; Parthasarathy, Krupakar; Lin, Xin; Jiang, Feng Li; Yu, Dejie; Vararattanavech, Ardcharaporn; Soong, Tuck Wah; Liu, Ding Xiang; Torres, Jaume
Title: Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel
  • Document date: 2009_7_10
    • ID: 1e102wrc_43
    Snippet: Although the precise role of this proposed channel activity is not known, it is possible that it leads to a subversion of ion homeostasis in the host cell that could account for the observed attenuation of E-deleted coronaviruses (see above). For example, in hepatitis B virus, calcium homeostasis regulation by HBx protein has been shown to be essential for replication [56] . It is also possible that the observed pro-apoptotic effect of SARS-CoV E.....
    Document: Although the precise role of this proposed channel activity is not known, it is possible that it leads to a subversion of ion homeostasis in the host cell that could account for the observed attenuation of E-deleted coronaviruses (see above). For example, in hepatitis B virus, calcium homeostasis regulation by HBx protein has been shown to be essential for replication [56] . It is also possible that the observed pro-apoptotic effect of SARS-CoV E protein in T cells [57] could be mediated by a disruption of cell ion homeostasis and membrane depolarization, a general marker of apoptosis [58] .

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