Selected article for: "cell apoptosis and host cell"
Author: Pervushin, Konstantin; Tan, Edward; Parthasarathy, Krupakar; Lin, Xin; Jiang, Feng Li; Yu, Dejie; Vararattanavech, Ardcharaporn; Soong, Tuck Wah; Liu, Ding Xiang; Torres, Jaume
Title: Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel
  • Document date: 2009_7_10
    • ID: 1e102wrc_43
    Snippet: Although the precise role of this proposed channel activity is not known, it is possible that it leads to a subversion of ion homeostasis in the host cell that could account for the observed attenuation of E-deleted coronaviruses (see above). For example, in hepatitis B virus, calcium homeostasis regulation by HBx protein has been shown to be essential for replication [56] . It is also possible that the observed pro-apoptotic effect of SARS-CoV E.....
    Document: Although the precise role of this proposed channel activity is not known, it is possible that it leads to a subversion of ion homeostasis in the host cell that could account for the observed attenuation of E-deleted coronaviruses (see above). For example, in hepatitis B virus, calcium homeostasis regulation by HBx protein has been shown to be essential for replication [56] . It is also possible that the observed pro-apoptotic effect of SARS-CoV E protein in T cells [57] could be mediated by a disruption of cell ion homeostasis and membrane depolarization, a general marker of apoptosis [58] .

    Search related documents:
    Co phrase search for related documents
    • calcium homeostasis and host cell: 1, 2, 3, 4
    • calcium homeostasis and ion homeostasis: 1, 2, 3, 4, 5, 6, 7
    • calcium homeostasis regulation and ion homeostasis: 1
    • cell ion and channel activity: 1, 2, 3, 4, 5, 6, 7
    • cell ion and host cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • cell ion and ion homeostasis: 1
    • cell ion and membrane depolarization: 1
    • cell ion homeostasis and ion homeostasis: 1
    • channel activity and host cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • channel activity and ion homeostasis: 1, 2, 3, 4
    • channel activity and membrane depolarization: 1, 2
    • channel activity and observed attenuation: 1