Author: Sun, Di; Chen, Shun; Cheng, Anchun; Wang, Mingshu
Title: Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells Document date: 2016_3_17
ID: 07nfb69o_52
Snippet: Picornaviral 3C pro serves as an attractive target for antiviral drugs against picornaviruses because it plays an essential role in the virus replication cycle and it does not have cellular homologues. Some small peptides and a ketone-containing tripeptide, known as peptide aldehydes, can inhibit 3C pro [124, 125] . The peptidyl aldehyde NK-1.8 k targets 3C pro to inhibit the replication of different EV71 strains and one EV68 strain [126] ......
Document: Picornaviral 3C pro serves as an attractive target for antiviral drugs against picornaviruses because it plays an essential role in the virus replication cycle and it does not have cellular homologues. Some small peptides and a ketone-containing tripeptide, known as peptide aldehydes, can inhibit 3C pro [124, 125] . The peptidyl aldehyde NK-1.8 k targets 3C pro to inhibit the replication of different EV71 strains and one EV68 strain [126] .
Search related documents:
Co phrase search for related documents- antiviral drug and essential role: 1, 2, 3, 4, 5, 6, 7, 8
- antiviral drug and replication cycle: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
- antiviral drug and small peptide: 1, 2, 3
- antiviral drug and virus replication cycle: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- antiviral drug attractive target and attractive target: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- antiviral drug attractive target and essential role: 1
- attractive target and essential role: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- attractive target and replication cycle: 1
- essential role and replication cycle: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- essential role and small peptide: 1
- essential role and virus replication cycle: 1
- essential role and virus replication cycle essential role: 1
- replication cycle and small peptide: 1
- replication cycle and virus replication cycle: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- replication cycle and virus replication cycle essential role: 1
Co phrase search for related documents, hyperlinks ordered by date