Selected article for: "respiratory pathogen and specific serotype"
Author: Abdel-Moneim, Ahmed S; El-Kady, Magdy F; Ladman, Brian S; Gelb, Jack
Title: S1 gene sequence analysis of a nephropathogenic strain of avian infectious bronchitis virus in Egypt
  • Document date: 2006_9_20
    • ID: 1in7m56w_1
    Snippet: Avian infectious bronchitis virus (IBV) is a highly contagious pathogen of chickens that replicates primarily in the respiratory tract and also in some epithelial cells of the gut, kidney and oviduct [1] . IBV is a virus member of genus Coronavirus, family Coronaviridae, order Nidovirales [2] . The virus possesses a positive stranded RNA genome that encodes phosphorylated nucleocapsid pro-tein (N), membrane glycoprotein (M), spike glycoprotein (S.....
    Document: Avian infectious bronchitis virus (IBV) is a highly contagious pathogen of chickens that replicates primarily in the respiratory tract and also in some epithelial cells of the gut, kidney and oviduct [1] . IBV is a virus member of genus Coronavirus, family Coronaviridae, order Nidovirales [2] . The virus possesses a positive stranded RNA genome that encodes phosphorylated nucleocapsid pro-tein (N), membrane glycoprotein (M), spike glycoprotein (S) and small membrane protein (E). The spike glycoprotein is post-translationally cleaved into two subunits, S1 and S2 [1, 3] . The S1 protein forms the N-terminal portion of the peplomer and contains antigenic epitopes mainly within three HVRs [4] [5] [6] . Neutralizing and serotype specific epitopes are associated within the defined HVRs [4, 7, 8] .

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