Selected article for: "expression level and mRNA expression level"
Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use
  • Document date: 2016_9_6
    • ID: 0s8huajd_135
    Snippet: In E. coli, when tandem rare codons, e.g. AGG AGG or AGA AGA, with correspondingly sparse tRNAs occur, frameshifting has been detected. When mRNAs containing such sequences are over-expressed, for instance when certain heterologous (mammalian) genes were expressed from multi-copy plasmids for biotechnological purposes, up to 50% frameshifting was detected (425) . However, with low mRNA levels the amount of frameshifting is greatly reduced, i.e. t.....
    Document: In E. coli, when tandem rare codons, e.g. AGG AGG or AGA AGA, with correspondingly sparse tRNAs occur, frameshifting has been detected. When mRNAs containing such sequences are over-expressed, for instance when certain heterologous (mammalian) genes were expressed from multi-copy plasmids for biotechnological purposes, up to 50% frameshifting was detected (425) . However, with low mRNA levels the amount of frameshifting is greatly reduced, i.e. the amount of frameshifting is mRNA expression level dependent (426, 427) .

    Search related documents:
    Co phrase search for related documents
    • expression level and low mrna: 1, 2, 3, 4, 5, 6
    • expression level and low mrna level: 1, 2
    • expression level and mammalian gene: 1, 2
    • expression level and mrna expression level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • expression level and rare codon: 1
    • expression level and sequence contain: 1
    • greatly reduce and mrna expression level: 1
    • heterologous mammalian gene and mammalian gene: 1, 2
    • low mrna and mammalian gene: 1
    • low mrna and mrna expression level: 1, 2, 3
    • low mrna and sequence contain: 1
    • low mrna level and mrna expression level: 1, 2
    • mrnas sequence contain and sequence contain: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • rare codon and tandem rare codon: 1, 2