Author: Kremer, Melanie; Suezer, Yasemin; Volz, Asisa; Frenz, Theresa; Majzoub, Monir; Hanschmann, Kay-Martin; Lehmann, Michael H.; Kalinke, Ulrich; Sutter, Gerd
Title: Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox Document date: 2012_3_1
ID: 0mmtcbof_14
Snippet: Recognition of invading pathogens by host cells is considered essential for activating innate and adaptive immune responses. Indeed as mentioned above, we confirmed a strong early activation of local innate immunity upon intranasal immunization ( Figure S3 ). Also in previous experiments with IFNAR 2/2 mice lacking the type I IFN receptor, we had found a somewhat lesser protective capacity of MVA vaccination [41] , indicating a role of sensing pa.....
Document: Recognition of invading pathogens by host cells is considered essential for activating innate and adaptive immune responses. Indeed as mentioned above, we confirmed a strong early activation of local innate immunity upon intranasal immunization ( Figure S3 ). Also in previous experiments with IFNAR 2/2 mice lacking the type I IFN receptor, we had found a somewhat lesser protective capacity of MVA vaccination [41] , indicating a role of sensing pathways that mediate recognition signals. This sensing is mainly achieved via Toll-like receptors (TLRs) and retinoic acidinducible gene-I (RIG-I)-like receptors (RLRs) [44] .
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