Author: Frieman, Matthew B.; Chen, Jun; Morrison, Thomas E.; Whitmore, Alan; Funkhouser, William; Ward, Jerrold M.; Lamirande, Elaine W.; Roberts, Anjeanette; Heise, Mark; Subbarao, Kanta; Baric, Ralph S.
Title: SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism Document date: 2010_4_8
ID: 15rtwl26_42
Snippet: Lungs of STAT12/2 mice infected with rMA15 virus progressed to an early stage pulmonary fibrosis-like disease in 9 days. The acute lung injury (ALI) seen in these lungs approximates the damage seen in ARDS that was often seen in severe cases of SARS in humans [50] , especially in the elderly. We found perivascular cuffing, collapse of alveolar parenchyma, invasion and amplification of macrophages, neutrophils, eosinophils and fibroblasts and most.....
Document: Lungs of STAT12/2 mice infected with rMA15 virus progressed to an early stage pulmonary fibrosis-like disease in 9 days. The acute lung injury (ALI) seen in these lungs approximates the damage seen in ARDS that was often seen in severe cases of SARS in humans [50] , especially in the elderly. We found perivascular cuffing, collapse of alveolar parenchyma, invasion and amplification of macrophages, neutrophils, eosinophils and fibroblasts and most importantly, extensive fibrin deposition throughout the lungs. These pathological findings mirror those seen in ALI, pulmonary fibrosis and ARDS.
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