Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_218
Snippet: ing that region, putatively precluding RNA with the extra A from being efficiently replicated. Though the slippagederived RNA is 1 nt longer than the genomic RNA, it is the functional equivalent of a sub-genomic RNA in that it is (putatively) not replicated and is template for the synthesis of a subset of viral products. Since in positive-sense RNA virus transcription, unlike in negative-sense RNA virus transcription, the template: nascent RNA du.....
Document: ing that region, putatively precluding RNA with the extra A from being efficiently replicated. Though the slippagederived RNA is 1 nt longer than the genomic RNA, it is the functional equivalent of a sub-genomic RNA in that it is (putatively) not replicated and is template for the synthesis of a subset of viral products. Since in positive-sense RNA virus transcription, unlike in negative-sense RNA virus transcription, the template: nascent RNA duplex is likely to extend a considerable distance behind the RNA polymerase footprint (possibly only being dissociated when the next polymerase passes), potyvirus slippage may require formation of a bulge nucleotide (42) .
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