Selected article for: "disease severe course and severe course"

Author: Stagegaard, Julia; Kurth, Andreas; Stern, Daniel; Dabrowski, Piotr Wojciech; Pocknell, Ann; Nitsche, Andreas; Schrick, Livia
Title: Seasonal recurrence of cowpox virus outbreaks in captive cheetahs (Acinonyx jubatus)
  • Document date: 2017_11_9
  • ID: 0oa4x05s_40
    Snippet: Because the outbreaks recurred on a yearly basis, all cheetahs were vaccinated in 2013 by using the Modified Vaccinia Ankara (MVA) smallpox vaccine which is widely used in elephants for prevention of clinical disease [33] . The same vaccination has already been used also in felids, but only sporadically, and information of antibody responses is limited [24] . All cheetahs were initially vaccinated with 2ml MVA twice, with a 4-week interval. Altho.....
    Document: Because the outbreaks recurred on a yearly basis, all cheetahs were vaccinated in 2013 by using the Modified Vaccinia Ankara (MVA) smallpox vaccine which is widely used in elephants for prevention of clinical disease [33] . The same vaccination has already been used also in felids, but only sporadically, and information of antibody responses is limited [24] . All cheetahs were initially vaccinated with 2ml MVA twice, with a 4-week interval. Although cluster 5 in 2014 was a group of vaccinated animals, one animal (Nova) was still infected with CPXV. This implies that the affected animal was not completely protected from disease, indicating that cheetahs might need a different vaccination regimen to that recommended in elephants. However, it is possible that the vaccination might have helped to prevent a more severe course of disease in Nova and infection of the siblings.

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