Author: Shields, Lauren E.; Jennings, Jordan; Liu, Qinfang; Lee, Jinhwa; Ma, Wenjun; Blecha, Frank; Miller, Laura C.; Sang, Yongming
Title: Cross-Species Genome-Wide Analysis Reveals Molecular and Functional Diversity of the Unconventional Interferon-? Subtype Document date: 2019_6_25
ID: 14gcu1se_48
Snippet: In addition to the major clusters of the unconventional IFN subtypes in livestock, we also detected some "outliers" per molecular signatures. For example, porcine IFN-δ1, -δ2, and -ω2, as well as bovine IFN-ω4 (Bb), -ω6 (Bt), -ω14 (Bb), -ω22 (Bt) show less sequence identity (<80%) overall to other members of the same IFN subtypes (Figures 2, 4) . As these members generally showed little antiviral activity in all our tests (9, 13, 23), we a.....
Document: In addition to the major clusters of the unconventional IFN subtypes in livestock, we also detected some "outliers" per molecular signatures. For example, porcine IFN-δ1, -δ2, and -ω2, as well as bovine IFN-ω4 (Bb), -ω6 (Bt), -ω14 (Bb), -ω22 (Bt) show less sequence identity (<80%) overall to other members of the same IFN subtypes (Figures 2, 4) . As these members generally showed little antiviral activity in all our tests (9, 13, 23), we also detected that these "outliers" of the unconventional IFN subtypes generally do not contain signal peptides for extracellular secretion of the mature IFN peptides (Figure 10 ) (10, 37) . This indicates that these "outliers" may represent a group of IFNs that mediate IFN responses via a newly identified intracellular pathway (10, 37) , or a non-canonical IFN signaling pathway to mediate some unknown functions (10, (37) (38) (39) .
Search related documents:
Co phrase search for related documents- antiviral activity and IFN response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- antiviral activity and IFN subtype: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- antiviral activity and IFNs group: 1, 2, 3, 4
- antiviral activity and intracellular pathway: 1, 2
- antiviral activity and little antiviral activity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- antiviral activity and livestock IFN subtype: 1
- antiviral activity and pathway signal: 1, 2, 3, 4, 5, 6, 7, 8
- antiviral activity and sequence identity: 1, 2, 3, 4, 5, 6
- antiviral activity and signal peptide: 1, 2, 3, 4, 5, 6, 7
- antiviral activity and unconventional IFN subtype: 1, 2
- extracellular secretion and IFN response: 1, 2
- extracellular secretion and IFN subtype: 1
- extracellular secretion and intracellular pathway: 1
- extracellular secretion and pathway signal: 1, 2
- extracellular secretion and signal peptide: 1, 2
- IFN peptide and pathway signal: 1
- IFN peptide and sequence identity: 1
- IFN response and IFNs group: 1, 2, 3, 4
- IFN response and intracellular pathway: 1
Co phrase search for related documents, hyperlinks ordered by date