Author: Kouokam, Joseph Calvin; Lasnik, Amanda B.; Palmer, Kenneth E.
Title: Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses Document date: 2016_11_17
ID: 096348l5_13
Snippet: Eight to 10 weeks old mice were administered 10 daily vaginal applications of 0.1% GRFT formulated in 40 µL Carbopol 974P, glycerin, ethylenediaminetetraacetic acid (EDTA), methyl-paraben, and propyl-paraben as previously described [9] . A matched Carbopol placebo gel containing all excipients but no GRFT was used as a negative control. For intraperitoneal treatment, mice were injected with 2 mg/kg GRFT in 100 µL of PBS or the same volume of ve.....
Document: Eight to 10 weeks old mice were administered 10 daily vaginal applications of 0.1% GRFT formulated in 40 µL Carbopol 974P, glycerin, ethylenediaminetetraacetic acid (EDTA), methyl-paraben, and propyl-paraben as previously described [9] . A matched Carbopol placebo gel containing all excipients but no GRFT was used as a negative control. For intraperitoneal treatment, mice were injected with 2 mg/kg GRFT in 100 µL of PBS or the same volume of vehicle for 10 days. Toxicity in both cases was assessed by measuring body and spleen weights as well as splenocyte activation.
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