Author: Wilson, Van G.
Title: Sumoylation at the Host-Pathogen Interface Document date: 2012_4_5
ID: 1awau7hm_39
Snippet: Overall, the conclusion from this section is that viruses have evolved many strategies to dysregulate host cell proteins through modulation of their post-translational modification with the SUMO paralogs. This has been most thoroughly explored for PML and related NB proteins that have anti-viral activity, but clearly occurs for other important cellular regulatory proteins such as p53 and pRB. Given the growing appreciation of how widely sumoylati.....
Document: Overall, the conclusion from this section is that viruses have evolved many strategies to dysregulate host cell proteins through modulation of their post-translational modification with the SUMO paralogs. This has been most thoroughly explored for PML and related NB proteins that have anti-viral activity, but clearly occurs for other important cellular regulatory proteins such as p53 and pRB. Given the growing appreciation of how widely sumoylation impacts many cellular processes, it is highly likely that other important viral attacks on host protein sumoylation will be identified in the future.
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