Selected article for: "respiratory tract infection and tract infection"
Author: Natalia Fintelman-Rodrigues; Carolina Q. Sacramento; Carlyle Ribeiro Lima; Franklin Souza da Silva; André C. Ferreira; Mayara Mattos; Caroline S. de Freitas; Vinicius Cardoso Soares; Suelen da Silva Gomes Dias; Jairo R. Temerozo; Milene Miranda; Aline R. Matos; Fernando A. Bozza; Nicolas Carels; Carlos Roberto Alves; Marilda M. Siqueira; Patrícia T. Bozza; Thiago Moreno L. Souza
Title: Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production
  • Document date: 2020_4_5
    • ID: 6zk0ioep_19
    Snippet: Recent reports on the COVID-19 outbreak have implicated that an increase in the levels of lactate dehydrogenase (LDH) and interleukin 6 (IL-6) is associated with mortality 22 . Viral infection in the respiratory tract often trigger the migration of blood monocytes to orchestrate the transition from innate to adaptive immune responses 23 . For these reasons, ATV and ATV/RTV were tested at suboptimal (1 μM) or optimal (10 μM) doses in a SARS-CoV-.....
    Document: Recent reports on the COVID-19 outbreak have implicated that an increase in the levels of lactate dehydrogenase (LDH) and interleukin 6 (IL-6) is associated with mortality 22 . Viral infection in the respiratory tract often trigger the migration of blood monocytes to orchestrate the transition from innate to adaptive immune responses 23 . For these reasons, ATV and ATV/RTV were tested at suboptimal (1 μM) or optimal (10 μM) doses in a SARS-CoV-2-infection model utilizing human primary monocytes.

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