Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_74
Snippet: Inserts of not just single nucleotides but blocks of nucleotides occur at 81 positions in the mitochondrial genome of the yeast Magnusiomyces capitatus and involve frame disruptions of 12 of the 15 protein coding genes (65) . Compensatory frame restorative translation permits mitochondrial function (65), with apparently similar inactivation avoidance in Saprochaete clavata (56) . This raises the issue of in-frame bypassing in at least certain oth.....
Document: Inserts of not just single nucleotides but blocks of nucleotides occur at 81 positions in the mitochondrial genome of the yeast Magnusiomyces capitatus and involve frame disruptions of 12 of the 15 protein coding genes (65) . Compensatory frame restorative translation permits mitochondrial function (65), with apparently similar inactivation avoidance in Saprochaete clavata (56) . This raises the issue of in-frame bypassing in at least certain other mitochondria with provocative sequence features that would result in a proportion of the product lacking some internal amino acids. Such in-frame translational bypassing was experimentally demonstrated with synthetic constructs in E. coli, and though in-frame stop hopping could be the explanation for certain cases of what is currently thought to be natural stop codon readthrough, no occurences are known.
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