Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_88
Snippet: Genes for magnesium chelatase from bacterial genera such as Pseudomonas and gold mineralizing Delftia and the archaea Methanocaldococcus and Methanococcus are organized in overlapping ORFs with an A AAA AAR sequence evolving under strong purifying selection suggesting that it is used as a shift site for evolutionarily conserved frameshifting (198) . Heterologous expression of several sequences from ORF overlaps demonstrated very high levels of fr.....
Document: Genes for magnesium chelatase from bacterial genera such as Pseudomonas and gold mineralizing Delftia and the archaea Methanocaldococcus and Methanococcus are organized in overlapping ORFs with an A AAA AAR sequence evolving under strong purifying selection suggesting that it is used as a shift site for evolutionarily conserved frameshifting (198) . Heterologous expression of several sequences from ORF overlaps demonstrated very high levels of frameshifting (198) , and regulatory potential merits investigation, keeping in mind that, though the gene is assigned the name magnesium chelatase, binding of something else, perhaps a different cation, could be relevant.
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