Author: Narendrula, Rashmi; Mispel-Beyer, Kyle; Guo, Baoqing; Parissenti, Amadeo M.; Pritzker, Laura B.; Pritzker, Ken; Masilamani, Twinkle; Wang, Xiaohui; Lannér, Carita
Title: RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines Document date: 2016_2_24
ID: 0mjizsoo_20
Snippet: Caspase-3 activity in extracts of control and docetaxeltreated cells was assayed by monitoring cleavage of a DEVD substrate using the CPP32 Colorimetric Assay Kit from BioVision Inc. (Milpitas, CA, USA). The effects of caspase-3 inhibition on docetaxel-induced caspase activity and docetaxel-dependent RNA disruption were determined by treating cells with and without docetaxel and/or the caspase-3 inhibitor, Q-DEVD-Oph (BioVision Inc., Milpitas, CA.....
Document: Caspase-3 activity in extracts of control and docetaxeltreated cells was assayed by monitoring cleavage of a DEVD substrate using the CPP32 Colorimetric Assay Kit from BioVision Inc. (Milpitas, CA, USA). The effects of caspase-3 inhibition on docetaxel-induced caspase activity and docetaxel-dependent RNA disruption were determined by treating cells with and without docetaxel and/or the caspase-3 inhibitor, Q-DEVD-Oph (BioVision Inc., Milpitas, CA, USA), and then assaying extracts of these cells for caspase-3 activity and RNA disruption as described above.
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