Author: El-Faham, Ayman; Farooq, Muhammad; Khattab, Sherine N.; Abutaha, Nael; Wadaan, Mohammad A.; Ghabbour, Hazem A.; Fun, Hoong-Kun
Title: Synthesis, Characterization, and Anti-Cancer Activity of Some New N'-(2-Oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazones Derivatives Document date: 2015_8_13
ID: 0dddrh4e_14
Snippet: The anti-cancer activity of the new prepared compounds against the HepG2 cell line revealed that compounds 3a, 3h, 4a, 4b, 4f, 4g, and 4h showed no anti-cancer activity. Similarly, the starting compounds 1 and 2 did not show promising anti-cancer activity in HepG2 cells. Compound 3e exhibited higher potency against HepG2 cell line with IC50 = 2.82 ± 40.7 μM, which is much lower than the IC50 value of 5-FU (32.15 ± 48.1 μM). Moreover, the resu.....
Document: The anti-cancer activity of the new prepared compounds against the HepG2 cell line revealed that compounds 3a, 3h, 4a, 4b, 4f, 4g, and 4h showed no anti-cancer activity. Similarly, the starting compounds 1 and 2 did not show promising anti-cancer activity in HepG2 cells. Compound 3e exhibited higher potency against HepG2 cell line with IC50 = 2.82 ± 40.7 μM, which is much lower than the IC50 value of 5-FU (32.15 ± 48.1 μM). Moreover, the results showed that compounds 3f, 4c, and 4e were also found to be potent and selective against HepG2 with IC50 values of 3.13 ± 42.0, 4.39 ± 43.2, and 7.61 ± 44.6 μM, respectively, which are also much lower than 5-FU ( Figure 5 and Table 3 ).
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