Author: Yadav, Yogesh; Sharma, Deepti; Kaushik, Kumar; Kumar, Vineet; Jha, Amitabh; Prasad, Ashok K.; Len, Christophe; Malhotra, Sanjay V.; Wengel, Jesper; Parmar, Virinder S.
Title: Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides Document date: 2019_10_30
ID: 15rg623y_33
Snippet: We successfully achieved the synthesis of twenty novel pyrazolyl nucleosides 3a-e, 4a-e, 5a-e, and 6a-e, which have been characterized in detail by using various NMR spectroscopic techniques such as 1 H NMR, 13 C NMR, NOESY, HMBC, etc. The pyrazolyl nucleosides 5a-e and 6a-e were screened for anticancer activities on 60 human tumor cell lines, and we identified one compound 6e, which showed good activity against 39 cancer cell lines and showed si.....
Document: We successfully achieved the synthesis of twenty novel pyrazolyl nucleosides 3a-e, 4a-e, 5a-e, and 6a-e, which have been characterized in detail by using various NMR spectroscopic techniques such as 1 H NMR, 13 C NMR, NOESY, HMBC, etc. The pyrazolyl nucleosides 5a-e and 6a-e were screened for anticancer activities on 60 human tumor cell lines, and we identified one compound 6e, which showed good activity against 39 cancer cell lines and showed significant inhibition against lung cancer cell line Hop-92 (GI 50 9.3 µM) and breast cancer cell line HS 578T (GI 50 3.0 µM). Our studies have demonstrated the potential of newly synthesized pyrazolyl-nucleosides that will be pursued further.
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