Author: Yuan, Yuan; Cao, Duanfang; Zhang, Yanfang; Ma, Jun; Qi, Jianxun; Wang, Qihui; Lu, Guangwen; Wu, Ying; Yan, Jinghua; Shi, Yi; Zhang, Xinzheng; Gao, George F.
Title: Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Document date: 2017_4_10
ID: 094lgjnn_15
Snippet: Implication for the design of broadly neutralizing antibodies. The S protein is the major antigen on the surface of the MERS-CoV or SARS-CoV virion. For MERS-CoV, most of the currently-available neutralizing antibodies were developed against the flexible RBD region [30] [31] [32] [33] [34] . For SARS-CoV, neutralizing antibodies against both S1 and S2 subunits have been developed 35, 36 . The accessibility of the RBD domain, due to its inherent f.....
Document: Implication for the design of broadly neutralizing antibodies. The S protein is the major antigen on the surface of the MERS-CoV or SARS-CoV virion. For MERS-CoV, most of the currently-available neutralizing antibodies were developed against the flexible RBD region [30] [31] [32] [33] [34] . For SARS-CoV, neutralizing antibodies against both S1 and S2 subunits have been developed 35, 36 . The accessibility of the RBD domain, due to its inherent flexibility, as shown in this study provides an explanation for the high efficiency of RBD-directed neutralizing antibodies. Since the RBD is located between the NTD domains, a strategy to develop neutralizing antibodies, which target the NTD and interfering with receptor binding through steric hindrance should be feasible in the future.
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