Author: Yuan, Yuan; Cao, Duanfang; Zhang, Yanfang; Ma, Jun; Qi, Jianxun; Wang, Qihui; Lu, Guangwen; Wu, Ying; Yan, Jinghua; Shi, Yi; Zhang, Xinzheng; Gao, George F.
Title: Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Document date: 2017_4_10
ID: 094lgjnn_8
Snippet: The MERS-CoV S ectodomain is a 140 Å long trimer with a triangular cross-section varying in diameter from 50 Å, at the membrane proximal base, to 140 Â 130 Å at the membrane distal head (Fig. 1a) , resembling a blooming flower. By contrast, the SARS-CoV S ectodomain has a smaller membrane distal head with dimensions of 135 Â 120 Å (Fig. 1b) . In the MERS-CoV or SARS-CoV S trimers, compared with the rest of the maps, the RBD region in the st.....
Document: The MERS-CoV S ectodomain is a 140 Å long trimer with a triangular cross-section varying in diameter from 50 Å, at the membrane proximal base, to 140 Â 130 Å at the membrane distal head (Fig. 1a) , resembling a blooming flower. By contrast, the SARS-CoV S ectodomain has a smaller membrane distal head with dimensions of 135 Â 120 Å (Fig. 1b) . In the MERS-CoV or SARS-CoV S trimers, compared with the rest of the maps, the RBD region in the standing state features weaker and poorer density and has lower local resolution (Supplementary Figs 7
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