Author: Tchitchek, Nicolas; Eisfeld, Amie J; Tisoncik-Go, Jennifer; Josset, Laurence; Gralinski, Lisa E; Bécavin, Christophe; Tilton, Susan C; Webb-Robertson, Bobbie-Jo; Ferris, Martin T; Totura, Allison L; Li, Chengjun; Neumann, Gabriele; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G
Title: Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice Document date: 2013_7_29
ID: 1qc72ovc_14
Snippet: Deletion of PB1-F2, K627E substitution in PB2, elimination of the HA multi-basic cleavage site, and truncation of NS1 all decreased VN1203 virulence in mice, and CA04-WT shows the lowest virulence in mice. We first aimed to determine whether the attenuated phenotype for each virus was the result of a different host response......
Document: Deletion of PB1-F2, K627E substitution in PB2, elimination of the HA multi-basic cleavage site, and truncation of NS1 all decreased VN1203 virulence in mice, and CA04-WT shows the lowest virulence in mice. We first aimed to determine whether the attenuated phenotype for each virus was the result of a different host response.
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