Author: Tchitchek, Nicolas; Eisfeld, Amie J; Tisoncik-Go, Jennifer; Josset, Laurence; Gralinski, Lisa E; Bécavin, Christophe; Tilton, Susan C; Webb-Robertson, Bobbie-Jo; Ferris, Martin T; Totura, Allison L; Li, Chengjun; Neumann, Gabriele; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G
Title: Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice Document date: 2013_7_29
ID: 1qc72ovc_27
Snippet: The main effect of VN1203-HAavir was also found to be an attenuated host response, with the VN1203-HAavir 10 4 dosage exhibiting an MDS projection and VC/MC profiles similar to that observed for VN1203 WT at the 10 3 dosage (Figures 4, and 5B ). The only difference was that VC and MC at 4 dpi were slightly lower than the VN1203-WT, while no difference in weight loss or viral replication was observed between the two viruses at that dpi......
Document: The main effect of VN1203-HAavir was also found to be an attenuated host response, with the VN1203-HAavir 10 4 dosage exhibiting an MDS projection and VC/MC profiles similar to that observed for VN1203 WT at the 10 3 dosage (Figures 4, and 5B ). The only difference was that VC and MC at 4 dpi were slightly lower than the VN1203-WT, while no difference in weight loss or viral replication was observed between the two viruses at that dpi.
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