Author: Frieman, Matthew B.; Chen, Jun; Morrison, Thomas E.; Whitmore, Alan; Funkhouser, William; Ward, Jerrold M.; Lamirande, Elaine W.; Roberts, Anjeanette; Heise, Mark; Subbarao, Kanta; Baric, Ralph S.
Title: SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism Document date: 2010_4_8
ID: 15rtwl26_14
Snippet: Lung virus titers in STAT12/2 mice were also higher at each timepoint tested compared to the titers seen in IFN receptor knockout and 129 WT mice, ( Figure 1B ). When infected with rMA15 virus, STAT12/2 mice showed higher peak virus titers in the lungs at day 2 (,10 8 pfu/g) that remained as high as .10 6 pfu/g at day 9 post-infection, while 129 WT mice had cleared the virus by 9 days. Urbani virus infected STAT12/2 mice also showed increased and.....
Document: Lung virus titers in STAT12/2 mice were also higher at each timepoint tested compared to the titers seen in IFN receptor knockout and 129 WT mice, ( Figure 1B ). When infected with rMA15 virus, STAT12/2 mice showed higher peak virus titers in the lungs at day 2 (,10 8 pfu/g) that remained as high as .10 6 pfu/g at day 9 post-infection, while 129 WT mice had cleared the virus by 9 days. Urbani virus infected STAT12/2 mice also showed increased and sustained virus replication in the lungs as late as 15 days post-infection while virus was detectable only through day 5 post-infection in the 129 WT mice ( Figure S1E ). Taken together, these data suggest that a STAT1-dependent, IFN type I and II receptor-independent pathway plays a key role in regulating viral clearance and survival following SARS-CoV infection.
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