Selected article for: "active site and RNA molecule"
Author: Myllykoski, Matti; Kursula, Petri
Title: Structural aspects of nucleotide ligand binding by a bacterial 2H phosphoesterase
  • Document date: 2017_1_31
    • ID: 0a3okta0_31
    Snippet: As the different structures predicted an RNA-binding surface on LigT, we further modeled a 3-residue RNA molecule with a terminal 2 0 -phosphate into the active site. Possible RNA recognition features can be deduced from this model (Fig 7D) , which fit to the binding determinants observed for different ligands crystallographically. The predicted binding mode includes both electrostatic interactions between Arg residues and the phospho groups, sta.....
    Document: As the different structures predicted an RNA-binding surface on LigT, we further modeled a 3-residue RNA molecule with a terminal 2 0 -phosphate into the active site. Possible RNA recognition features can be deduced from this model (Fig 7D) , which fit to the binding determinants observed for different ligands crystallographically. The predicted binding mode includes both electrostatic interactions between Arg residues and the phospho groups, stacking of bases against aromatic residues, and C-H. . .Ï€ interactions of the ribose rings.

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