Author: Pervushin, Konstantin; Tan, Edward; Parthasarathy, Krupakar; Lin, Xin; Jiang, Feng Li; Yu, Dejie; Vararattanavech, Ardcharaporn; Soong, Tuck Wah; Liu, Ding Xiang; Torres, Jaume
Title: Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel Document date: 2009_7_10
ID: 1e102wrc_36
Snippet: For cells infected with MHV, the EC 50 for HMA was ,4 mM, whereas in an E-deleted virus (MHVDE), no effect was observed after HMA addition, pointing to E protein as the HMA target [36] . HMA also inhibited HCoV-229E replication in cultured cells, with an EC 50 of ,1 mM. In neither case, however, did amiloride have antiviral activity on replication in cultured cells. Consistent with these results, we show that channel activity of transfected mamma.....
Document: For cells infected with MHV, the EC 50 for HMA was ,4 mM, whereas in an E-deleted virus (MHVDE), no effect was observed after HMA addition, pointing to E protein as the HMA target [36] . HMA also inhibited HCoV-229E replication in cultured cells, with an EC 50 of ,1 mM. In neither case, however, did amiloride have antiviral activity on replication in cultured cells. Consistent with these results, we show that channel activity of transfected mammalian cells expressing SARS-CoV E is inhibited by extracellular HMA, but not by amiloride, suggesting a specific activity.
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