Author: Andrabi, Raiees; Pallesen, Jesper; Allen, Joel D.; Song, Ge; Zhang, Jinsong; de Val, Natalia; Gegg, Gavin; Porter, Katelyn; Su, Ching-Yao; Pauthner, Matthias; Newman, Amanda; Bouton-Verville, Hilary; Garces, Fernando; Wilson, Ian A.; Crispin, Max; Hahn, Beatrice H.; Haynes, Barton F.; Verkoczy, Laurent; Ward, Andrew B.; Burton, Dennis R.
Title: The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template Document date: 2019_5_21
ID: 1ni7949q_39
Snippet: Interestingly, the trimer-elicited serum Ab responses in the CH01 UCA KI model mapped entirely to the glycan N160, as probed by ELISA binding with MT145K, CRF250 trimers, and their N160-glycan-eliminated trimer variants ( Figure S9 ). The animals, however, did not develop Env backbone-specific off-target B cell responses at any stages of the SIV MT145K or HIV trimer immunizations. This result suggests that the very high frequency of CH01 UCA prec.....
Document: Interestingly, the trimer-elicited serum Ab responses in the CH01 UCA KI model mapped entirely to the glycan N160, as probed by ELISA binding with MT145K, CRF250 trimers, and their N160-glycan-eliminated trimer variants ( Figure S9 ). The animals, however, did not develop Env backbone-specific off-target B cell responses at any stages of the SIV MT145K or HIV trimer immunizations. This result suggests that the very high frequency of CH01 UCA precursor B cells in the mouse model favors V2-apex responses to the exclusion of off-target responses. Therefore, this model was ultimately found to be unsuitable for evaluation of the advantages of a combined HIV and SIV immunization strategy and an adoptive transfer approach that can generate inter-epitope B cell clonal competition (Abbott et al., 2018; Dosenovic et al., 2018) may be more revealing.
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