Author: Andrabi, Raiees; Pallesen, Jesper; Allen, Joel D.; Song, Ge; Zhang, Jinsong; de Val, Natalia; Gegg, Gavin; Porter, Katelyn; Su, Ching-Yao; Pauthner, Matthias; Newman, Amanda; Bouton-Verville, Hilary; Garces, Fernando; Wilson, Ian A.; Crispin, Max; Hahn, Beatrice H.; Haynes, Barton F.; Verkoczy, Laurent; Ward, Andrew B.; Burton, Dennis R.
Title: The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template Document date: 2019_5_21
ID: 1ni7949q_42
Snippet: Vaccination has taken advantage of related viruses from different species, beginning with the use of cowpox as a smallpox vaccine (Riedel, 2005) . HIV is too variable and has too many evasion mechanisms for such an approach applied directly to work effectively. Nevertheless, there are HIV-related viruses that have the potential to be exploited in some form in vaccine design. Indeed, the HIV pandemic is believed to have arisen because of a crosssp.....
Document: Vaccination has taken advantage of related viruses from different species, beginning with the use of cowpox as a smallpox vaccine (Riedel, 2005) . HIV is too variable and has too many evasion mechanisms for such an approach applied directly to work effectively. Nevertheless, there are HIV-related viruses that have the potential to be exploited in some form in vaccine design. Indeed, the HIV pandemic is believed to have arisen because of a crossspecies virus transmission from chimpanzees to humans during the period from 1910 to 1930 (Korber et al., 2000; Sharp and Hahn, 2011; Worobey et al., 2008) . The HIV and chimpanzee SIV Envs, the target of potentially protective neutralizing antibodies, display about 60% sequence conservation at the amino-acid level. Importantly, HIV V2-apex bnAbs have been shown to neutralize certain chimpanzee SIV isolates, including the SIVcpzPtt isolate MT145, suggesting cross-species conservation of this epitope (Barbian et al., 2015) . Accordingly, we generated a chimpanzee SIV Env trimer (MT145 SOSIP) and showed that it bound HIV V2-apex bnAbs. We then engineered it to bind to germline-reverted V2-apex bnAbs (MT145K SOSIP) so that it might be useful in activating V2-apex precursors.
Search related documents:
Co phrase search for related documents- amino acid and effectively work: 1, 2
- amino acid and Env trimer: 1, 2, 3, 4
- amino acid and evasion mechanism: 1, 2
- amino acid and HIV bnabs: 1, 2, 3, 4, 5, 6
- amino acid and neutralizing antibody: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59
- amino acid and related virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- amino acid and sequence conservation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35
- amino acid and smallpox vaccine: 1
- amino acid and vaccine design: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66
- amino acid level and neutralizing antibody: 1
- amino acid level and related virus: 1, 2, 3, 4
- amino acid level and sequence conservation: 1, 2
- amino acid level and vaccine design: 1
- amino acid level sequence conservation and sequence conservation: 1
Co phrase search for related documents, hyperlinks ordered by date