Author: Laine, Romain F.; Albecka, Anna; van de Linde, Sebastian; Rees, Eric J.; Crump, Colin M.; Kaminski, Clemens F.
Title: Structural analysis of herpes simplex virus by optical super-resolution imaging Document date: 2015_1_22
ID: 0zchxz00_1
Snippet: T he Herpesviridae comprise a large family of enveloped DNA viruses that infect a wide range of hosts, including humans. One of the most widespread human members of this family, herpes simplex virus type-1 (HSV-1), is a common cause of cold sores but can also result in herpes keratitis 1 , a leading infectious cause of blindness, and herpes simplex encephalitis 2 , which has a high mortality even in patients treated with antiviral therapy. It is .....
Document: T he Herpesviridae comprise a large family of enveloped DNA viruses that infect a wide range of hosts, including humans. One of the most widespread human members of this family, herpes simplex virus type-1 (HSV-1), is a common cause of cold sores but can also result in herpes keratitis 1 , a leading infectious cause of blindness, and herpes simplex encephalitis 2 , which has a high mortality even in patients treated with antiviral therapy. It is highly contagious and can be easily passed from individual to individual via direct contact. In addition, after primary infection, HSV-1 establishes a lifelong latent infection in sensory ganglia with periodic reactivation of the virus leading to both symptomatic and asymptomatic virus shedding 3 .
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