Author: Tchitchek, Nicolas; Eisfeld, Amie J; Tisoncik-Go, Jennifer; Josset, Laurence; Gralinski, Lisa E; Bécavin, Christophe; Tilton, Susan C; Webb-Robertson, Bobbie-Jo; Ferris, Martin T; Totura, Allison L; Li, Chengjun; Neumann, Gabriele; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G
Title: Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice Document date: 2013_7_29
ID: 1qc72ovc_5
Snippet: To unravel this interplay, we performed a systematic characterization of the global host response at the transcript and protein levels in lungs of mice infected by a panel of viruses that vary in pathogenicity, using a range of inoculation dosages. We also report a systematic collection of several corresponding phenotypic variables, including mouse body weights, lung virus titers, viral messenger RNA, and viral genomic RNA for each infected anima.....
Document: To unravel this interplay, we performed a systematic characterization of the global host response at the transcript and protein levels in lungs of mice infected by a panel of viruses that vary in pathogenicity, using a range of inoculation dosages. We also report a systematic collection of several corresponding phenotypic variables, including mouse body weights, lung virus titers, viral messenger RNA, and viral genomic RNA for each infected animal. Our panel of viruses included the A/Vietnam/1203/2004 [H5N1] wild-type virus (VN1203-WT), the lower pathogenicity A/California/04/2009 [H1N1] wild-type virus (CA04-WT), two previously described VN1203 mutant viruses -VN1203-HAavir [2] and VN1203-PB2-627E [4] and two newly generated VN1203 mutant viruses -VN1203-NS1trunc and H5N1 VN1203-PB1F2del.
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