Author: Tchitchek, Nicolas; Eisfeld, Amie J; Tisoncik-Go, Jennifer; Josset, Laurence; Gralinski, Lisa E; Bécavin, Christophe; Tilton, Susan C; Webb-Robertson, Bobbie-Jo; Ferris, Martin T; Totura, Allison L; Li, Chengjun; Neumann, Gabriele; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G
Title: Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice Document date: 2013_7_29
ID: 1qc72ovc_5
Snippet: To unravel this interplay, we performed a systematic characterization of the global host response at the transcript and protein levels in lungs of mice infected by a panel of viruses that vary in pathogenicity, using a range of inoculation dosages. We also report a systematic collection of several corresponding phenotypic variables, including mouse body weights, lung virus titers, viral messenger RNA, and viral genomic RNA for each infected anima.....
Document: To unravel this interplay, we performed a systematic characterization of the global host response at the transcript and protein levels in lungs of mice infected by a panel of viruses that vary in pathogenicity, using a range of inoculation dosages. We also report a systematic collection of several corresponding phenotypic variables, including mouse body weights, lung virus titers, viral messenger RNA, and viral genomic RNA for each infected animal. Our panel of viruses included the A/Vietnam/1203/2004 [H5N1] wild-type virus (VN1203-WT), the lower pathogenicity A/California/04/2009 [H1N1] wild-type virus (CA04-WT), two previously described VN1203 mutant viruses -VN1203-HAavir [2] and VN1203-PB2-627E [4] and two newly generated VN1203 mutant viruses -VN1203-NS1trunc and H5N1 VN1203-PB1F2del.
Search related documents:
Co phrase search for related documents- H1N1 wild type virus and mutant virus: 1
- H1N1 wild type virus and wild type: 1, 2, 3, 4
- H1N1 wild type virus and wild type virus: 1, 2, 3, 4
- host response and infect animal: 1, 2, 3
- host response and inoculation dosage: 1, 2
- host response and low pathogenicity: 1, 2
- host response and lung virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
- host response and lung virus titer: 1
- host response and mutant virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- host response and protein transcript: 1, 2, 3, 4, 5
- host response and systematic characterization: 1, 2
- host response and virus panel: 1
- host response and wild type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- host response and wild type virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- infect animal and low pathogenicity: 1
Co phrase search for related documents, hyperlinks ordered by date