Author: Tchitchek, Nicolas; Eisfeld, Amie J; Tisoncik-Go, Jennifer; Josset, Laurence; Gralinski, Lisa E; Bécavin, Christophe; Tilton, Susan C; Webb-Robertson, Bobbie-Jo; Ferris, Martin T; Totura, Allison L; Li, Chengjun; Neumann, Gabriele; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G
Title: Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice Document date: 2013_7_29
ID: 1qc72ovc_16
Snippet: Functional enrichment analysis of the biological conditions also indicated a large degree of overlap in the host responseat least qualitativelyirrespective of the virus used to infect the mice. For instance, Acute Phase Response Signaling, Antigen Presentation Pathway, LXR/RXR Altogether, these results demonstrate that it is mainly the magnitude of expression changes within the same transcripts or proteins, rather than the induction of different .....
Document: Functional enrichment analysis of the biological conditions also indicated a large degree of overlap in the host responseat least qualitativelyirrespective of the virus used to infect the mice. For instance, Acute Phase Response Signaling, Antigen Presentation Pathway, LXR/RXR Altogether, these results demonstrate that it is mainly the magnitude of expression changes within the same transcripts or proteins, rather than the induction of different gene sets, that differentiate the host response to CA04-WT, VN1203-WT, and H5N1 VN1203 mutants. Thus, isogenic viruses and different inoculation dosages likely trigger the same differentially regulated genes, but with different degrees of magnitude at both the transcriptomic and proteomic levels. This analysis was performed on the transcriptomic and proteomic levels independently, and in parallel. Though we noted this magnitude effect was stronger in the proteomic dataset compared to the transcriptomic dataset, we found the same conclusions in each separate analysis.
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