Author: Laine, Romain F.; Albecka, Anna; van de Linde, Sebastian; Rees, Eric J.; Crump, Colin M.; Kaminski, Clemens F.
Title: Structural analysis of herpes simplex virus by optical super-resolution imaging Document date: 2015_1_22
ID: 0zchxz00_24
Snippet: From our measurements, we propose a model for HSV-1 tegument architecture (Fig. 4b) . In addition, this model includes the current understanding of the interaction and antibodybinding sites of the considered proteins in the tegument. Indeed, we have previously shown that VP16 binds to VP1/2 within the first 361 amino acids of VP1/2 (ref. 14) . Moreover, the binding site of VP1/2 to pUL37 has been localized within the C-terminal region of pUL37 (r.....
Document: From our measurements, we propose a model for HSV-1 tegument architecture (Fig. 4b) . In addition, this model includes the current understanding of the interaction and antibodybinding sites of the considered proteins in the tegument. Indeed, we have previously shown that VP16 binds to VP1/2 within the first 361 amino acids of VP1/2 (ref. 14) . Moreover, the binding site of VP1/2 to pUL37 has been localized within the C-terminal region of pUL37 (ref. 11). The diameter measured for pUL37 (153.8 nm) is in good agreement with published data showing that the interaction site of VP1/2 with pUL37 is close to the VP16 interaction domain, within the amino terminus of VP1/2 (ref. 44) , potentially placing both VP16 and pUL37 in a similar location relative to VP1/2.
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