Selected article for: "activation release and adaptive innate"
Author: ten Oever, Jaap; Kox, Matthijs; van de Veerdonk, Frank L; Mothapo, Khutso M; Slavcovici, Adriana; Jansen, Tim L; Tweehuysen, Lieke; Giamarellos-Bourboulis, Evangelos J; Schneeberger, Peter M; Wever, Peter C; Stoffels, Monique; Simon, Anna; van der Meer, Jos WM; Johnson, Melissa D; Kullberg, Bart-Jan; Pickkers, Peter; Pachot, Alexandre; Joosten, Leo AB; Netea, Mihai G
Title: The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases
  • Document date: 2014_11_19
    • ID: 0zkeoa1z_1
    Snippet: Toll-like receptors (TLRs) are germline-encoded receptors that recognize microbial structures called pathogenassociated molecular patterns (PAMPs), either alone or in combination with co-receptors. Besides regulating innate and adaptive immune responses, TLR signaling plays an important role in the pathogenesis of several inflammatory diseases, and tight regulation is crucial in order to prevent hyperinflammation [1, 2] . Immune signaling is regu.....
    Document: Toll-like receptors (TLRs) are germline-encoded receptors that recognize microbial structures called pathogenassociated molecular patterns (PAMPs), either alone or in combination with co-receptors. Besides regulating innate and adaptive immune responses, TLR signaling plays an important role in the pathogenesis of several inflammatory diseases, and tight regulation is crucial in order to prevent hyperinflammation [1, 2] . Immune signaling is regulated at multiple levels, and the release of extracellular domains of immune receptors such as cytokine receptors represents an important regulatory mechanisms [3] . Similar negative regulation accounts for modulation of TLR function [1, 2] , and soluble forms of TLR2 and TLR4 have been recently described [4, 5] . The release of these soluble proteins increases upon cell activation and they exert inhibitory activity on TLR signaling [4, 5] . Soluble forms of TLRs have been detected in pleural fluid, amniotic fluid, saliva, breast milk and plasma [4, [6] [7] [8] [9] [10] .

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