Author: Pervushin, Konstantin; Tan, Edward; Parthasarathy, Krupakar; Lin, Xin; Jiang, Feng Li; Yu, Dejie; Vararattanavech, Ardcharaporn; Soong, Tuck Wah; Liu, Ding Xiang; Torres, Jaume
Title: Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel Document date: 2009_7_10
ID: 1e102wrc_27
Snippet: To test the inhibitory effect of HMA, cells were exposed to 10 mM HMA in the bath solution. This significantly reduced the whole cell current flowing through SARS-CoV E protein; indeed, the mean peak current at 70 mV was reduced by ,60% (P,0.02, unpaired ttest) (Fig. 7C) . Amiloride, in contrast, reduced the mean peak current by only ,25%, although this difference was not statistically significant (P.0.05, unpaired t-test) (Fig. 7D) . In this fig.....
Document: To test the inhibitory effect of HMA, cells were exposed to 10 mM HMA in the bath solution. This significantly reduced the whole cell current flowing through SARS-CoV E protein; indeed, the mean peak current at 70 mV was reduced by ,60% (P,0.02, unpaired ttest) (Fig. 7C) . Amiloride, in contrast, reduced the mean peak current by only ,25%, although this difference was not statistically significant (P.0.05, unpaired t-test) (Fig. 7D) . In this figure, we note that the peak current for transfected cells recorded in panel B, ,600 pA, is larger than that in panels C and D, of ,200 pA. We attribute these differences to variation in cDNA preparation, transfection, and the time of recording following transfection.
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