Author: Schmaljohn, Alan L.; Orlandi, Chiara; Lewis, George K.
Title: Deciphering Fc-mediated Antiviral Antibody Functions in Animal Models Document date: 2019_7_17
ID: 1755sywc_28
Snippet: As illustrated in Figure 3 , animal models may be employed to examine effectiveness of Ab given at various times before (prophylactically) or after (therapeutically) the cognate Ag, in this case viral antigen either on virions or cells. Interpretations of outcomes are in some respects straightforward. However, behind the superficial simplicity of Abs including CTAb that may evoke Fc-dependent antiviral effector function, there exists a complex ar.....
Document: As illustrated in Figure 3 , animal models may be employed to examine effectiveness of Ab given at various times before (prophylactically) or after (therapeutically) the cognate Ag, in this case viral antigen either on virions or cells. Interpretations of outcomes are in some respects straightforward. However, behind the superficial simplicity of Abs including CTAb that may evoke Fc-dependent antiviral effector function, there exists a complex array of binding and signaling events, each with its own quantitative and qualitative dimensions. To simplify, these are illustrated in Figure 4 as building blocks required to reach a (26) Examine Ab-mediated protection in (knockout) mice lacking discrete FcR-bearing cell lineages
Search related documents:
Co phrase search for related documents- animal model and knockout mouse: 1
- antiviral effector function and effector function: 1, 2, 3, 4, 5
- cell lineage and effector function: 1
Co phrase search for related documents, hyperlinks ordered by date