Author: Qiu, Yingshan; Lam, Jenny K. W.; Leung, Susan W. S.; Liang, Wanling
Title: Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside Document date: 2016_9_20
ID: 04pp3lv0_56
Snippet: Many transcription factors including nuclear factor-κB (NF-κB) [168] , signal transducer and activator of transcription factor 6 (STAT6) [166] and GATA-binding protein 3 (GATA3) [170] are involved in the production T h 2 cytokine in the airways of patients with asthma. They were investigated as targets for RNAi in the management of asthmatic inflammation. NF-κB plays a key role in the expression of many pro-inflammatory proteins [191] . Inhibi.....
Document: Many transcription factors including nuclear factor-κB (NF-κB) [168] , signal transducer and activator of transcription factor 6 (STAT6) [166] and GATA-binding protein 3 (GATA3) [170] are involved in the production T h 2 cytokine in the airways of patients with asthma. They were investigated as targets for RNAi in the management of asthmatic inflammation. NF-κB plays a key role in the expression of many pro-inflammatory proteins [191] . Inhibition of NF-κB pathway in the lungs was reported to be beneficial in asthma model [176, 192] . One approach to inhibit the activation of NF-κB signaling pathway is to target receptor-interacting protein 2 (Rip2), which is a transcriptional product and an activator of NF-κB. Suppression of Rip2 expression was achieved in mice by intratracheal delivery of siRNA, resulting in the inhibition of ovalbumin (OVA)-induced cytokine release, inflammatory cell infiltration, mucus hypersecretion and serum IgE level. This result suggested that Rip2 could be a novel therapeutic target for the treatment of asthma [168] . Consistent with this finding, suppression of STAT6 [10] and GATA3 [170, 193] in murine model of allergen-induced asthma by RNAi significantly inhibited the expression of downstream T h 2 cytokines. These studies support the hypothesis of using RNAi molecules targeting transcription factors to manage airway inflammation and AHR of asthma.
Search related documents:
Co phrase search for related documents- activator signal transducer and asthma model: 1
- activator signal transducer and cell infiltration: 1
- activator signal transducer and cytokine release: 1, 2
- activator signal transducer and key role: 1, 2, 3, 4
- activator signal transducer and murine model: 1, 2
- activator signal transducer and NF κB pathway: 1, 2, 3
- activator signal transducer and NF κB signal pathway: 1
- activator signal transducer and NF κB signal pathway activation: 1
- activator signal transducer and nuclear factor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29
- activator signal transducer and signal pathway: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30
- activator signal transducer and signal transducer: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- activator signal transducer and therapeutic target: 1, 2, 3, 4, 5
- activator signal transducer and transcription factor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39
- activator signal transducer and transcription factor target: 1, 2
- AHR airway inflammation and airway inflammation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- AHR airway inflammation and asthma AHR airway inflammation: 1
- AHR airway inflammation and asthma model: 1, 2
- AHR airway inflammation and asthma treatment: 1, 2
- AHR airway inflammation and asthmatic inflammation: 1
Co phrase search for related documents, hyperlinks ordered by date