Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice

Tchitchek, Nicolas; Eisfeld, Amie J; Tisoncik-Go, Jennifer; Josset, Laurence; Gralinski, Lisa E; Bécavin, Christophe; Tilton, Susan C; Webb-Robertson, Bobbie-Jo; Ferris, Martin T; Totura, Allison L; Li, Chengjun; Neumann, Gabriele; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G

Additional file 5: Table S3 . Magnitude and Velocity Coefficients and the phenotypical variables for each transcriptomic biological condition. For each transcriptomic biological condition, the Magnitude Coefficient (MC)quantifying the Euclidian distance to the matched mock-infected conditionand the Velocity Coefficient (VC)quantifying the speed of the host response to move to the next time pointare indicated as well as the mean of mice body weight loss (mean body weight) and the difference of the means of viral titer (Δ mean viral titer), viral mRNA (Δ mean viral mRNA), and mean viral genomic RNA (Δ mean viral gRNA) between two consecutive time-points.