Selected article for: "active site and catalytic mechanism"
Author: Myllykoski, Matti; Kursula, Petri
Title: Structural aspects of nucleotide ligand binding by a bacterial 2H phosphoesterase
  • Document date: 2017_1_31
    • ID: 0a3okta0_9
    Snippet: For an insight into the active-site properties and catalytic mechanism, we co-crystallized LigT with different nucleotide compounds in the active site (Table 1, Fig 2) , including substrates, products, and other compounds. In addition to the presumed obvious substrates and products, we also used other nucleotide compounds in an attempt to screen LigT crystallographically for nucleotide-like ligand-binding properties. This was considered of intere.....
    Document: For an insight into the active-site properties and catalytic mechanism, we co-crystallized LigT with different nucleotide compounds in the active site (Table 1, Fig 2) , including substrates, products, and other compounds. In addition to the presumed obvious substrates and products, we also used other nucleotide compounds in an attempt to screen LigT crystallographically for nucleotide-like ligand-binding properties. This was considered of interest, as open questions remain related to the physiological function of both LigT and many 2H family enzymes in general. All structures had more than one protein chain in the asymmetric unit, and in general, the one with best-defined electron density for ligands was used in the analyses below.

    Search related documents:
    Co phrase search for related documents
    • active site and best define: 1
    • active site and catalytic mechanism: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • active site and compound product: 1
    • active site and electron density: 1, 2, 3, 4, 5, 6, 7
    • active site and family enzyme: 1, 2, 3, 4, 5, 6, 7, 8
    • active site and ligand bind: 1, 2, 3, 4
    • asymmetric unit and electron density: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • catalytic mechanism and family enzyme: 1