Author: Huang, Qiu Sue; Turner, Nikki; Baker, Michael G; Williamson, Deborah A; Wong, Conroy; Webby, Richard; Widdowson, Marc-Alain
Title: Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance Document date: 2015_6_9
ID: 1pfqgvie_14
Snippet: There is increasing evidence in the literature for the importance of polymicrobial infections. However, there remain gaps in our understanding of respiratory virus codetection and whether this represents co-infection and affects clinical disease manifestations and severity. There are contradictory reports with some suggesting that co-infections increase the severity of respiratory disease, 19-23 while others have found either no association [24] .....
Document: There is increasing evidence in the literature for the importance of polymicrobial infections. However, there remain gaps in our understanding of respiratory virus codetection and whether this represents co-infection and affects clinical disease manifestations and severity. There are contradictory reports with some suggesting that co-infections increase the severity of respiratory disease, 19-23 while others have found either no association [24] [25] [26] [27] [28] or that co-infections may actually be protective. 29 Additionally, bacterial coinfections associated with cases of influenza are a leading cause of severe morbidity and mortality: bacterial coinfections complicated nearly all influenza deaths in the 1918 pandemic and up to 34% of the 2009 A(H1N1)pdm09 infections managed in intensive care units worldwide. 30, 31 SHIVERS will help our understanding of the potential role of pathogen co-detection in patient outcome, severity, aetiology, demography and underlying risk conditions.
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