Author: Fan, Qing; Kopp, Sarah J.; Connolly, Sarah A.; Longnecker, Richard
Title: Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype Document date: 2017_5_16
ID: 1v6nf28a_1
Snippet: in gD that is proposed to signal the gH/gL heterodimer to trigger the fusogenic activity of gB (1) (2) (3) . Entry receptors that bind to gD include herpesvirus entry mediator (HVEM) (4), nectin-1 (5, 6) , nectin-2 (7, 8) , and modified heparan sulfate (HS) (9, 10) . Another receptor, paired immunoglobulin-like type 2 receptor (PILRâ£), binds to gB and can mediate viral entry, provided that gD also binds to a receptor (11) ......
Document: in gD that is proposed to signal the gH/gL heterodimer to trigger the fusogenic activity of gB (1) (2) (3) . Entry receptors that bind to gD include herpesvirus entry mediator (HVEM) (4), nectin-1 (5, 6) , nectin-2 (7, 8) , and modified heparan sulfate (HS) (9, 10) . Another receptor, paired immunoglobulin-like type 2 receptor (PILRâ£), binds to gB and can mediate viral entry, provided that gD also binds to a receptor (11) .
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