Author: Wilson, Van G.
Title: Sumoylation at the Host-Pathogen Interface Document date: 2012_4_5
ID: 1awau7hm_33
Snippet: The previous section described pathogens and pathogen proteins that targeted sumoylation enzymes to cause broad effects on multiple host SUMO substrates. This section will focus on how pathogens modulate sumoylation of specific target proteins. As might be anticipated, the target proteins identified to date include critical host cell regulators of growth or pathogen resistance, such as p53, pRB, PML, and Daxx. All of these host proteins are known.....
Document: The previous section described pathogens and pathogen proteins that targeted sumoylation enzymes to cause broad effects on multiple host SUMO substrates. This section will focus on how pathogens modulate sumoylation of specific target proteins. As might be anticipated, the target proteins identified to date include critical host cell regulators of growth or pathogen resistance, such as p53, pRB, PML, and Daxx. All of these host proteins are known to be regulated by sumoylation, so it not surprising that pathogens have developed strategies to dysregulate these proteins through modulation of their sumoylation status.
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